|
KMID : 0869619980150010061
|
|
Journal of Korean Society of Hospital Pharmacists
1998 Volume.15 No. 1 p.61 ~ p.64
|
|
|
A Retrospective Study of Adverse Effects of Amphotercin B Diluted in 5% Dextrose Solution
|
|
김미리/Kim, My Ri
한혜원/양유리/김재연/노환성/Han, Hae Won/Yang, You Ri/Kim, Jae Youn/Ro, Hwan Seong
|
|
|
Abstract
|
|
|
|
The clinical use of amphotericin B is sometimes limited by nephrotoxicity and other adverse effects. In a retrospective study, the adverse effects(nephrotoxicity, headache, fever, chills, nausea, vomiting) induced by amphotericin B of 32 patients(mean age 47, ranging from 17 to 65) treated for haematological malignancies who received amphotericin B in 5% dextrose were monitored. 47%(15/32) of the patients showed adverse effect; fever, headache, chills, nausea/vomiting, nephrotoxicity and hypokalemia showed in 22%, 13%, 9%, 9%, 60%, 25% each. The administration was interrupted by intolerance in 4 cases, by death or hopeless discharge in 5 cases, and was improved in 6 cases. Mean total dosage was 449.5㎎(11∼965㎎) and the mean duration of administration was 12.5days(1∼37days).
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|